Studien & Forschung

Efficacy and safety of medical marijuana in migraine headache: A systematic review

Kopfschmerzen/Migräne

Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: Randomized, double-blind and controlled placebo clinical trial

Autismus

Cannabinoid use in a tertiary headache clinic: A cross-sectional survey

Kopfschmerzen/Migräne

Cannabidiol in Treatment of Autism Spectrum Disorder: A Case Study

Fallstudie von 2022: Rückgang der negativen Verhaltensweisen, ohne Nebenwirkungen jeglicher Art Nachdem der Junge über einen gewissen Zeitraum zweimal täglich mit CBD-Öl behandelt wurde, war ein „Rückgang der negativen Verhaltensweisen, einschließlich der gewalttätigen Ausbrüche, des selbstverletzenden Verhaltens und seiner Schlafstörungen“ festzustellen. Zudem gab es eine Verbesserung der sozialen Interaktionen, der Konzentration und seiner emotionalen Stabilität, ohne dass Nebenwirkungen jeglicher Art auftraten. Verbesserte Schlafzeit und -qualität (8-10 Stunden pro Nacht) Verbesserte schulische Leistungen Regelmäßiges Essen Minimales selbstverletzendes Verhalten Reduzierte unangemessene Verhaltensweisen Kann einfachen Anweisungen folgen


Autismus

Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind and controlled placebo clinical trial

Studie von 2022: Erhebliche Verbesserungen im Sozialverhalten, bei Angst und Unruhe in 12 Wochen Die randomisierte, doppelblinde, placebokontrollierte klinische Studie zur Bewertung der Wirksamkeit und Sicherheit CBD reichen Cannabisextrakts zeigte bei 60 autistischen Kindern im Alter zwischen 5 und 11 Jahren über einen Zeitraum von 12 Wochen folgende signifikanten Ergebnisse gegenüber der Placebogruppe: Soziale Interaktion [F(1.116)=14,13, p=0,0002)] Angst [F(1.116)=5,99, p=0,016] psychomotorische Unruhe [F(1.116)=9,22, p=0,003)] Anzahl der Mahlzeiten pro Tag [F(1,116)=4,11, p=0,04)] Konzentration [F(1,48)=6,75, p=0,01], (nur bei leichter ASD signifikant)

Autismus

Human studies and case reports have documented improvements in ASD patients following the administration of various cannabinoid formulations.

Autismus

Are cannabis, cannabis-derived products, and synthetic cannabinoids a therapeutic tool for rheumatoid arthritis? A friendly summary of the evidence

Arthritis

A phase II randomized clinical trial assessing the tolerability of two different ratios of medicinal cannabis in patients with high grade gliomas

The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients.

Fibromyalgie

Cannabis use assessment and its impact on pain in rheumatologic disease: A systematic review and meta-analysis.

Fibromyalgie

Use of medical cannabis by patients with fibromyalgia in Canada after cannabis legalization: A cross-sectional study.

Fibromyalgie

Cannabidiol use for fibromyalgia: Prevalence of use and perception of effectiveness in a large online survey.

Fibromyalgie

Long-term safety and efficacy of highly purified cannabidiol for treatment of refractory epilepsy.

Epilepsie

Clinical outcome data of first cohort of chronic pain patients treated with cannabis-based sublingual oils in the United Kingdom – analysis from the UK Medical Cannabis Registry

Chronische Schmerzen

Cannabinoids for the treatment of refractory neuropathic pruritus in amyotrophic lateral sclerosis: a case report

Hautausschläge/Hautreizungen

Treatment of chronic pruritus with medical marijuana

Hautausschläge/Hautreizungen

Within-subject, double-blinded, randomized, and placebo-controlled evaluation of the combined effects of the cannabinoid dronabinol and the opioid hydromorphone in a human laboratory model

Chronische Schmerzen

Therapeutic and cosmetic uses of cannabis: Cannabinoids for acne treatment and skin rejuvenation

Hautausschläge/Hautreizungen

The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: A randomized cross-over clinical trial

Stress/PTBS

Use of cannabinoids for the treatment of patients with post-traumatic stress disorder

Stress/PTBS

A randomized trial of medical cannabis patients with stage IV cancers to assess feasibility, dose requirements, impact on pain and opioid use, safety, and overall patient satisfaction

Chronische Schmerzen

Medical cannabis for the treatment of fibromyalgia syndrome: A retrospective, open-label case series

Chronische Schmerzen

150 adolescents with autism. decrease disruptive behaviors associated with ASD

A placebo-controlled clinical trial reported that the administration of whole-plant cannabis extracts were safe and effective in a cohort of 150 adolescents with autism. Researchers reported: “In this study, we have demonstrated for the first time in a placebo-controlled trial that cannabinoid treatment has the potential to decrease disruptive behaviors associated with ASD, with acceptable tolerability. … Disruptive behavior on the CGI-I [Clinical Global Impression-Improvement scale] was either much or very much improved in 49 percent [of subjects taking] whole-plant extract versus 21 percent on placebo. Median SRS [Social Responsiveness Scale] Total Score (secondary-outcome) improved by 14.9 [points] on whole-plant extract versus 3.6 points after placebo.

Autismus

Patient-reported outcomes in those consuming medical cannabis: A prospective longitudinal observational study in chronic pain patients

Chronische Schmerzen

Cannabis significantly reduces the use of prescription opioids and improves quality of life in authorized patients: Results of a large prospective study

Chronische Schmerzen

A 15-year-old patient with autism after adding low doses of CBD/THC extracts adjunctively. Improved within six months

2021 Canadian researchers documented the successful treatment of a 15-year-old patient with autism after adding low doses of CBD/THC extracts adjunctively. Researchers reported that the patient’s symptoms improved within six months of treatment, and that he had experienced “positive effects on his behavioral symptoms, anxiety, sleep, and social deficits” since that time.

Autismus

Cannabis and cannabinoid use in autism spectrum disorder: A systematic review

Autismus

A pediatric patient with autism spectrum disorder and epilepsy using cannabinoid extract as complementary therapy: A case report

Autismus

CBD-enriched cannabis for autism spectrum disorder: An experience of a single center in Turkey and reviews of the literature

Autismus

Cannabinoid treatment for autism: A proof-of-concept randomized trials

Autismus

Safety and efficacy of low-dose medical cannabis oils in multiple sclerosis

Multiple Sklerose

Experience of migraine, its severity, and perceived efficacy of treatments among cannabis users

Kopfschmerzen/Migräne

Cardiovascular Effects of Medical Marijuana: A Systemic Review

Hypertonie

Cannabis is associated with blood pressure reduction in older adults: A 24-hours ambulatory blood pressure monitoring study

Hypertonie

Association between marijuana use and cardiovascular disease in US adults

Hypertonie

A systemic review and meta-analysis of randomized controlled trials for cardiovascular toxicity of medical cannabinoids

Hypertonie

Cannabinoids in the management of frontotemporal dementia: A case series

Alzheimer/Demenz

Cannabinoids and bladder symptoms in multiple sclerosis

Magen-Darm-Beschwerden

Safety and efficacy of medicinal cannabis in the treatment of fibromyalgia: A systematic review.

Fibromyalgie

Medical cannabis for the treatment of fibromyalgia syndrome: A retrospective, open-label case series.

Fibromyalgie

The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis

Arthritis

Autism spectrum disorder and medical cannabis: Review and clinical experience

Autismus

Association of Marijuana Use and Cardiovascular Disease: A Behavioral Risk Factor Surveillance System Data Analysis of 133,706 US Adults

Hypertonie

Illicit cannabis use as a management strategy in New Zealand women with endometriosis

Magen-Darm-Beschwerden

The pharmacokinetics, efficacy, and safety of a novel selective-dose inhaler in patients with chronic pain: A randomized, double-blinded, placebo-controlled trial

Chronische Schmerzen

The potential role of cannabinoids in dermatology

Hautausschläge/Hautreizungen

Adding medical cannabis to standard analgesic treatment for fibromyalgia: A prospective observational trial.

Fibromyalgie

Cannabis use assessment and its impact on pain in rheumatologic diseases: A systematic review and meta-analysis

Arthritis

Cannabis use for restless legs syndrome and uremic pruritus in patients with maintenance dialysis: A survey

Hautausschläge/Hautreizungen

Ingestion of THC-rich cannabis oil in people with fibromyalgia: A randomized, double-blind, placebo-controlled clinical trial.

Fibromyalgie

Cannabinoids in dermatology: Hope or hype?

Hautausschläge/Hautreizungen

Cannabisnoid use among Americans with MS: Current trends and gaps in knowledge

Multiple Sklerose

Therapeutic potential of cannabidiol for skin health and disorders

Hautausschläge/Hautreizungen

Survey Shows CBD Has Positive Impact on Migraines

Herstellerumfrage: 86 % berichteten von einer Verringerung der Kopfschmerzen nach 30 Tagen. Am Ende des 30-tägigen Testzeitraums berichteten 86 % der Befragten von einer Verringerung der Kopfschmerzen. Teilnehmer mit chronischer Migräne hatten eine 33%ige Verringerung ihrer Kopfschmerztage.

Kopfschmerzen/Migräne

Alleviative effects of cannabis flower on migraine and headache

Kopfschmerzen/Migräne

“Marijuana for Migraine? Some Tentative Evidence.”

Kopfschmerzen/Migräne

Migraine frequency decrease following prolonged medical cannabis treatment: A cross-sectional study

Kopfschmerzen/Migräne

Characteristics of medical cannabis usage among patients with fibromyalgia.

Fibromyalgie

30% of Migraine Sufferers in American Have Tried Cannabis For Migraine Relief.

Kopfschmerzen/Migräne

Cognitive function and adaptive skills after a one-year trial of cannabidiol (CBD) in a pediatric sample with treatment resistant epilepsy.

Epilepsie

Association between cannabis use and healthcare utilization in patients with irritable bowel syndrome: A retrospective cohort study

Magen-Darm-Beschwerden

Effects of Delta-9-tetrahydrocannabinol on aversive memories and anxiety: a review from human studies

Stress/PTBS

The Long-Term, Prospective, Therapeutic Impact of cannabis on Post-Traumatic Stress Disorder

Stress/PTBS

Consensus-based recommendations for titrating cannabinoids and tapering opioids for chronic pain control

Chronische Schmerzen

Cannabis use and post-traumatic stress disorder: prospective evidence from a longitudinal study of veterans

Stress/PTBS

Emerging promise of cannabinoids for the management of pain and associated neuropathological alterations of Alzheimer’s disease

Alzheimer/Demenz

Cannabinoids improve gastrointestinal symptoms in a parenteral nutrition–dependent patient with chronic intestinal pseudo-obstruction

Magen-Darm-Beschwerden

Children and young adults with ASD consumed either cannabis or hemp-based products. reported 60-91 percent improvements

In 2020, US researchers affiliated with Tufts University in Boston reported on their clinical experience working with children and young adults with ASD who had consumed either cannabis or hemp-based products. Among subjects with ASD-associated aggression, 60 percent reported improvements following treatment. Among subjects diagnosed with both ASD and epilepsy, 91 percent reported some improvement in seizure control.

Autismus

Impact of cannabis on non-medical opioid-use and symptoms of post-traumatic stress disorder: A nationwide longitudinal VA study

Stress/PTBS

Short and long-term effects of cannabis on symptoms of post-traumatic stress disorder

Stress/PTBS

Cannabidiol: A killer for inflammatory rheumatoid arthritis synovial fibroblasts

Arthritis

Researchers unlock access to pain relief potential of cannabis

Chronische Schmerzen

Patterns of Marijuana Use and Health Impact: A Survey Among Older Coloradans

Chronische Schmerzen

Multiple Sclerosis and use of medical cannabis: A retrospective review evaluating symptom outcomes

Chronische Schmerzen

Lower circulating endocannabinoid levels in children with autism spectrum disorder

Autismus

Effects of CBD-enriched cannabis sativa extract on autism spectrum disorder symptoms: An observational study of 18 participants undergoing compassionate use

Autismus

Real life experiences of medical cannabis treatment in autism: Analysis of safety and efficacy

Autismus

Oral cannabidiol use in children in with autism spectrum disorder to treat related symptoms and co-morbidities

Autismus

Marijuana use among patients with epilepsy at a tertiary care center

Epilepsie

Cannabis use among patients in a large US rheumatic disease registry.

Fibromyalgie

Safety and efficacy of medical cannabis in fibromyalgia.

Fibromyalgie

Nabilone administration in refractory chronic diarrhea: A case series

Magen-Darm-Beschwerden

Impact of cannabinoids on symptoms of refractory gastroparesis: A single-center experience

Magen-Darm-Beschwerden

Association between cannabis use and complications related to ulcerative colitis in hospitalized patients

Magen-Darm-Beschwerden

Medical cannabis for inflammatory bowel disease: Real-life experience of mode of consumption and assessment of side effects

Magen-Darm-Beschwerden

Association between cannabis use and complications related to Crohn’s disease: A retrospective cohort study

Magen-Darm-Beschwerden

Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol

Concomitant treatment of malignant brain tumors with CBD: A case series and review of the literature

Cannabidiol–from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

Short- and Long-Term Efects of Cannabis on Headache and Migraine

Kopfschmerzen/Migräne

Multiple Sclerosis and use of medical cannabis: A retrospective review evaluating symptom outcomes

Multiple Sklerose

Does cannabis use modify the effect of post-traumatic stress disorder on severe depression and suicidal ideation? Evidence from a population-based cross-sectional study of Canadians

Stress/PTBS

Combined tetrahydrocannabinol and cannabidiol to treat pain in epidermolysis bullosa: A report of three cases

Hautausschläge/Hautreizungen

Cannabidiol in Anxiety and Sleep: A Large Case Series

Beobachtungsstudie von 2019: Innerhalb von 4 Wochen erlebten 66,7 % eine Verbesserung des Schlafes Fallserie mit 72 Erwachsenen über 3 Monate. 66,7 % der Patienten erlebten eine Verbesserung des Schlafes innerhalb von 4 Wochen. Zwei Monate nach Beginn der CBD-Behandlung berichteten 56,1 % der Patienten über einen verbesserten Schlaf im Vergleich zur vorherigen monatlichen Befragung.

Schlafstörungen

Cannabidiol in Anxiety and Sleep: A Large Case Series

Beobachtungsstudie von 2019: Deutlich weniger Angst bei fast 80 % der Teilnehmer innerhalb von 4 Wochen PatientInnen mit Angsterkrankungen erfuhren bereits nach einer kurzen Einnahmezeit (1 Monat) eine signifikante Verbesserung ihrer Symptome. Vor der Behandlung zeigte sich ein mittleres Ergebnis von 23,8 auf der oben beschriebenen Skala zur Erfassung der Angstsymptome. Durch die Einnahme von CBD konnte dieser Wert auf 18 während des ersten Monats und folgend auf 16 nach zwei Monaten der Behandlung gesenkt werden. Diese Reduktion der Symptome auf einen Wert von 16 blieb über den Verlauf des dritten Monats konstant, was den signifikanten und stabilen Rückgang der Angstsymptome verdeutlicht.

Zur Untersuchung des Therapieerfolgs wurden die PatientInnen vor Beginn der Therapie mit CBD körperlich untersucht und erhielten verschiedene validierte Fragebögen zur Selbsteinschätzung ihrer Symptome. Der Fragebogen zur Erfassung der Angstsymptome beinhaltete 14 Fragen, deren Antworten jeweils ein Zahlenwert zugeordnet wurde. Insgesamt konnte ein Zahlenwert von 56 erreicht werden. Ein Wert unter 17 ist ein Hinweis auf das Vorliegen einer leichten Angsterkrankung, während ein Wert über 25 als schwere Angsterkrankung eingestuft wird. 79,1 % der Teilnehmer haben deutlich weniger Angst Innerhalb von 4 Wochen von "mittlerer Angsterkrankung" (23,8 Punkte) zu "leichter Angsterkrankung" (16 Punkte) Stabiler Rückgang der Angstsymptome über den Beobachtungszeitraum von 3 Monaten

Ängste

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

Studie von 2019: Verbesserungen der Lebensqualität bei 94 % innerhalb 8 Wochen Ziel ist es, die Auswirkungen von Cannabidiol (CBD) aus Vollhanfextrakt auf den Opioidkonsum und die Indikatoren für die Lebensqualität bei chronischen Schmerzpatienten zu untersuchen. Mehr als die Hälfte der Patienten mit chronischen Schmerzen (53 %) reduzierten oder eliminierten ihre Opioide innerhalb von 8 Wochen, nachdem sie CBD-reichen Hanfextrakt zu ihrer Therapie hinzugefügt hatten. Fast alle CBD-Anwender (94 %) berichteten von Verbesserungen der Lebensqualität. Die Ergebnisse zeigen, dass die Verwendung des CBD-reichen Extrakts es unseren Patienten ermöglichte, Opioide zu reduzieren oder zu eliminieren, was zu einer signifikanten Verbesserung ihrer Lebensqualität führte.


Chronische Schmerzen

Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities

Studie von 2019: Hyperaktivitätssymptome besserten sich bei 68,4 % der Teilnehmer innerhalb von 2 Monaten 53 Kinder im mittleren Alter von 11 (4–22) Jahren erhielten Cannabidiol für eine mittlere Dauer von 66 Tagen. Selbstverletzung und Wutanfälle verbesserten sich bei 67,6 % Hyperaktivitätssymptome besserten sich bei 68,4 % Schlafprobleme verbesserten sich bei 71,4 % Angst besserte sich bei 47,1 %

Autismus

CBD extracts was associated with improved ASD symptoms in 14 out of 15 adolescent subjects

2019 a Brazilian observational trial reported that the twice-daily administration of plant-derived CBD extracts was associated with improved ASD symptoms in 14 out of 15 adolescent subjects

Autismus

Children with ASD have been found to possess lower-than-normal levels of certain endogenous cannabinoids, including anandamide.

Autismus

The consumption of cannabis by fibromyalgia patients in Israel.

Fibromyalgie

A prospective open-label trial of a CBD/THC cannabis oil in Dravet syndrome.

Epilepsie

Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy

Studie von 2018: Verbesserungen der Symptome bei über 90 % der Kinder Von den Patienten, die die Fragebögen zur Nachsorge beantworteten (93 Patienten), berichteten 90,2 % von ihnen eine Verbesserung der Symptome nach sechsmonatiger Behandlung. Folgende Symptome verbesserten sich: Anfällen, Tics, Depression, Unruhe, Wutattacken, Angst, Erregung, Schlafstörungen, Verdauungsprobleme, Verstopfung Verbesserung der Lebensqualität bei 35 % der Patienten Verbesserung beim Schlaf, positive Stimmung, Fähigkeit sich selbständig anzuziehen und zu duschen. 34 % der Patienten konnten ihre Medikation reduzieren. Inkl. Antipsychotika, Antiepileptika, Antidepressiva und Beruhigungsmittel.

Autismus

Lifetime marijuana use and subclinical atherosclerosis: The Coronary Artery Risk Development in Young Adults (CARDIA) study

Hypertonie

Self-initiated use of topical cannabidiol oil for epidermolysis bullosa

Hautausschläge/Hautreizungen

CBD-dominant cannabis extracts led to significant improvements in over 60 percent of ASD patients with refractory behavioral problems.

Autismus

CBD extracts resulted in “overall improvements” in a cohort of 53 children with ASD.

Autismus

Medical cannabis for the treatment of fibromyalgia.

Fibromyalgie

Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability

Chronische Schmerzen

Effect of adding medical cannabis treatment to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study.

Fibromyalgie

Cannabinoids in dermatology: A scoping review

Hautausschläge/Hautreizungen

Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly

Chronische Schmerzen

Report of objective clinical responses of cancer patients to pharmaceutical-grade synthetic cannabidiol

Cannabidiol-based medical cannabis in children with autism: A retrospective feasibility study

Autismus

The endocannabinoid system and autism spectrum disorders: Insights from animal models

Autismus

Cannabinoids suitable for migraine prevention.

Kopfschmerzen/Migräne

Cannabis reverses aging process in the brain, study suggests

Alzheimer/Demenz

A cross-sectional survey of medical cannabis users: Patterns of use and perceived efficacy

Kopfschmerzen/Migräne

Cannabis as a substitute for opioid-based pain medication: Patient self-report

Chronische Schmerzen

The endocannabinoid system and its role in eczematous dermatoses

Hautausschläge/Hautreizungen

Preferences for medical marijuana over prescription medications among persons living with chronic conditions

Magen-Darm-Beschwerden

Drug-herb interactions in the elderly patient with IBD: A growing concern

Magen-Darm-Beschwerden

Cannabinoids may soothe certain skin diseases, say researchers

Hautausschläge/Hautreizungen

Medicinal uses of marijuana and cannabinoids

Chronische Schmerzen

Cannabinoids for treating inflammatory bowel diseases: Where are we and where do we go?

Magen-Darm-Beschwerden

Cannabis use among patients at a comprehensive cancer center in a state with legalized medicinal and recreational use

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes

Diabetes

Systematic review of the potential role of cannabinoids as antiproliferative agents for urological cancers

Cannabis and multiple sclerosis: The way forward

Multiple Sklerose

Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis

Arthritis

The role of cannabinoids in dermatology

Hautausschläge/Hautreizungen

Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep

Kopfschmerzen/Migräne

Cannabis use in palliative oncology: A review of the evidence for popular indications

Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study

Diabetes

Cannabis use in people with Parkinson’s disease and Multiple Sclerosis: A Web-based investigation

Multiple Sklerose

The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research

Chronische Schmerzen

GW Pharmaceuticals achieves positive results in Phase 2 proof of concept study in glioma

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Studie von 2017: 50 Prozent weniger Anfälle bei Dravet-Syndrom
 Placebo-kontrollierte Doppelblindstudie in der einen Monat lang die Wirkung von Cannabidiol an 120 Kindern und jungen Erwachsenen, die unter einem Dravet-Syndrom mit therapieresistenten Anfällen litten, untersucht wurde. CBD wurde zusätzlich zu den Medikamenten eingenommen. Anzahl der Anfälle konnten von 12,4 auf 5,9 (Mittelwert pro Monat) gesenkt werden. Fünf Prozent der Patienten in der CBD Gruppe erreichten sogar eine Anfallsfreiheit Kaum Veränderungen in der Kontrollgruppe

Epilepsie

Modulation of the endocannabinoid system has been suggested as a target for ASD therapies

Autismus

Cannabidiol (CBD) significantly reduces drop seizure frequency in Lennox-Gastaut syndrome (LGS)

Studie von 2017: Rückgang der Anfälle um 44 % bei Lennox-Gastaut-Syndrom 171 Patienten mit Lennox-Gastaut-Syndrom. Auch hier nahmen die Probanden begleitend zum CBD Antiepileptika, reduzierten die Dosis jedoch im Vergleich zu vor der Untersuchung um die Hälfte Im Mittelwert konnte durch das Cannabidiol innerhalb von vier Wochen ein Rückgang der Anfälle um 44 Prozent beobachtet werden Unterschied zwischen 10 und 20 mg CBD pro Kg Körpergewicht minimal.

Epilepsie

Low-dose cannabidiol is safe but not effective in the treatment for Crohn’s disease, a randomized controlled trial

Magen-Darm-Beschwerden

The use of cannabis for headache disorders

Kopfschmerzen/Migräne

Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders

Stress/PTBS

Efficacy and tolerability of phytomedicines in multiple sclerosis patients: A review

Multiple Sklerose

Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

Studie von 2016: Abnahme der Angst und stetige Verbesserung der Schlafqualität und -quantität Angst- und Schlafstörungen sind häufig die Folge von großem Stress. Diese Studie mit Cannabidiolöl (CBD) führte zu einer anhaltenden Abnahme der Angst und einer stetigen Verbesserung der Schlafqualität und -quantität des Patienten.

Schlafstörungen

THC:CBD observational study data: Evolution of resistant MS spasticity and associated symptoms

Multiple Sklerose

Metabolic Syndrome Among Marijuana Users in the United States: An Analysis of National Health and Nutrition Examination Survey Data

Diabetes

Migraine, fibromyalgia, irritable bowel, and other treatment-resistent syndromes

Fibromyalgie

Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

Studie von 2016: Abnahme der Angst und stetige Verbesserung der Schlafqualität und -quantität Diese Studie beschäftigt sich hauptsächlich mit der Wirkung, die CBD auf Symptome von Erkrankungen haben kann. CBD soll eine sehr positive Wirkung auf Angststörungen haben. Viele ADHS Betroffene leiden unter Angstzuständen, die bestimmte Symptome wie Unruhe und Konzentrationsschwierigkeiten noch verschlimmern können. Es gibt mittlerweile einige Studien, die eine positive CBD Wirkung belegen. Eine Studie ergab, dass CBD bei der Behandlung von Angstzuständen erfolgreich war. Diese Studie ist besonders interessant, da ein 10-jähriges Mädchen behandelt wurde und somit auch die Verabreichung von CBD bei Kindern ein Thema war. Schlaflosigkeit ist auch etwas, mit dem ADHS Betroffene zu kämpfen haben. In Studien konnte bereits eine Verbesserung der Schlafqualität festgestellt werden, wenn die Probanden CBD einnahmen. Außerdem soll CBD auch in der Lage sein, übermäßige Schläfrigkeit am Tag zu bekämpfen. Das hört sich paradox an, konnte aber in Studien beobachtet werden. Diese Studie mit Cannabidiolöl (CBD) führte zu einer anhaltenden Abnahme der Angst und einer stetigen Verbesserung der Schlafqualität und -quantität des Patienten.

ADHS

Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.

Epilepsie

Cannabidiol as a potential treatment for febrile infection-related epilepsy syndrome (FIRES) in the acute and chronic phases

Epilepsie

Results of Epidiolex Trial in Lennox-Gastaut Syndrone announced

Epilepsie

Does medical marijuana oil work? UAB shares insight into Carly’s Law study

Epilepsie

CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience

Epilepsie

Therapeutic use of cannabis in Inflammatory Bowel Disease

Magen-Darm-Beschwerden

Marijuana use in adults admitted to a Canadian epilepsy monitoring unit

Epilepsie

Metabolic syndrome in people with a psychotic illness: is cannabis protective?

Diabetes

Attitudes to cannabis and patterns of use among Canadians with multiple sclerosis

Multiple Sklerose

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population

Studie von 2016: Reduzierung der Migräneanfälle um 50 % Die Häufigkeit von Migränekopfschmerzen sank von 10,4 auf 4,6 Kopfschmerzen pro Monat.

Kopfschmerzen/Migräne

Estimating the Relationship between Marijuana Use and Body Mass Index

Diabetes

An exploratory human laboratory experiment evaluating vaporized cannabis in the treatment of neuropathic pain from spinal cord injury and disease

Chronische Schmerzen

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis

Tierstudie von 2016: CBD reduzierte Gelenkschwellungen signifikant CBD-Gel reduzierte signifikant Gelenkschwellungen, Infiltration von Immunzellen und Verdickung der Synovialmembran bei Ratten.

Arthritis

Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases: A systematic review of randomized controlled trials

Arthritis

Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells

Integrating cannabis into clinical care

Medical cannabis use is associated with decreased opiate medication use in a retrospective cross-sectional survey of patients with chronic pain

Chronische Schmerzen

Safety and efficacy of medical cannabis oil for behavioral and psychological symptom of dementia: An open label, add-on, pilot study

Alzheimer/Demenz

Mental health symptom severity in cannabis using and non-using Veterans with probable PTSD

Stress/PTBS

Clinical Endocannbinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistent Syndromes

Kopfschmerzen/Migräne

The use of medical-grade cannabis in patients non-responders to nabiximols.

Multiple Sklerose

Effects of medical marijuana on migraine headache frequency in an adult population

Kopfschmerzen/Migräne

Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

Studie von 2016: Abnahme der Angst und stetige Verbesserung der Schlafqualität und -quantität Angst- und Schlafstörungen sind häufig die Folge von großem Stress. Diese Studie mit Cannabidiolöl (CBD) führte zu einer anhaltenden Abnahme der Angst und einer stetigen Verbesserung der Schlafqualität und -quantität des Patienten.

Ängste

Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells

Alzheimer/Demenz

Patterns of cannabis use in patients with Inflammatory Bowel Disease: A population based analysis

Magen-Darm-Beschwerden

Efficacy of inhaled cannabis on painful diabetic neuropathy

Chronische Schmerzen

Marijuana chemical shows promise for hard-to-treat epilepsy in kids

Epilepsie

Cannabis Smoking and Diabetes Mellitus: Results from Meta-Analysis with Eight Independent Replication Samples

Diabetes

Cannabis for the Management of Pain: Assessment of Safety Study

Chronische Schmerzen

Drug–drug interaction between clobazam and cannabidiol in children with refractory epilepsy.

Epilepsie

Neuroprotection in experimental autoimmune encephalomyelitis and progressive multiple sclerosis by cannabis-based cannabinoids

Multiple Sklerose

The endocannabinoid system and its therapeutic implications in rheumatoid arthritis

Arthritis

Medical marijuana liquid extract may bring hope for children with severe epilepsy

Epilepsie

Association between cannabis use and the risk of bladder cancer: Results from the California Men’s Health Study

The use of cannabinoids as anticancer agents

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

Epilepsie

Efficacy of inhaled cannabis on painful diabetic neuropathy

Diabetes

Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome

Epilepsie

Cannabis use in relation to obesity and insulin resistance in the inuit population

Diabetes

Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy

Epilepsie

Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache

Kopfschmerzen/Migräne

Medical cannabis in Arizona: Patient characteristics, perceptions, and impressions of medical cannabis legalization

Fibromyalgie

Cannabis use provides symptom relief in patients with inflammatory bowel disease but is associated with worse disease prognosis in patients with Crohn’s disease

Magen-Darm-Beschwerden

Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment

Stress/PTBS

Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know

Hypertonie

Use of a synthetic cannabinoid in a correctional population for posttraumatic stress disorder-related insomnia and nightmares, chronic pain, harm reduction, and other indications: a retrospective evaluation

Stress/PTBS

Preliminary, open-label, pilot study of add-on oral delta-9-tetrahydrocannabinol in chronic post-traumatic stress disorder

Stress/PTBS

The pharmacokinetics, efficacy, safety, and ease of use of a novel portable metered-dose cannabis inhaler in patients with chronic neuropathic pain: a phase 1a study

Chronische Schmerzen

Cannabis for inflammatory bowel disease

Magen-Darm-Beschwerden

Therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

Fibromyalgie

PTSD symptom reports of patients evaluated for the New Mexico Medical Cannabis Program

Stress/PTBS

Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy

Epilepsie

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study

Stress/PTBS

Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms

The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

Diabetes

Low-dose vaporized cannabis significantly improves neuropathic pain

Chronische Schmerzen

Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules

Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers

Chronische Schmerzen

Marijuana stops child’s severe seizures

Epilepsie

Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study

Magen-Darm-Beschwerden

Marijuana use on glucose, insulin, and insulin resistance among US adults

Diabetes

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation

Marijuana use patterns among patients with inflammatory bowel disease

Magen-Darm-Beschwerden

Cannabinergic pain medicine: a concise clinical primer and survey of randomized-controlled trial results

Chronische Schmerzen

Prescribing cannabis for harm reduction

Chronische Schmerzen

Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects

Multiple Sklerose

Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence

Stress/PTBS

Decreased prevalence of diabetes in marijuana users

Diabetes

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer

The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications

Association of herbal cannabis use with negative psychosocial parameters in patients with fibromyalgia

Fibromyalgie

Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial

Multiple Sklerose

Cannabinoid facilitation of fear extinction memory recall in humans

Stress/PTBS

Cannabis use among patients with inflammatory bowel disease

Magen-Darm-Beschwerden

Cannabiniod-opioid interaction in chronic pain

Chronische Schmerzen

Obesity and cannabis use: results from 2 representative national surveys

Diabetes

Cannabis use in patients with fibromyalgia: Effect on symptoms relief and health-related quality of life.

Fibromyalgie

Treatment of Crohn’s disease with cannabis: an observational study

Magen-Darm-Beschwerden

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials

Metastudie über Cannabinoide: 83 % der Studien haben positive Ergebnisse Eine systematische Überprüfung von 18 Studien über die Wirkung von Cannabinoiden (CBD und THC), die 925 Patienten mit chronischen Schmerzen untersuchten, zeigte, dass 83 % der Studien positive Ergebnisse hatten. Zu den ausgewerteten chronischen Schmerzdiagnosen gehörten neuropathische Schmerzen, Fibromyalgie und rheumatoide Arthritis 83 % der Studien zur Wirkung von Cannabinoiden haben positive Ergebnisse. Diagnosen u.a.: neuropathische Schmerzen, Fibromyalgie und rheumatoide Arthritis.

Chronische Schmerzen

Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas–possible role of cannabis inhalation

Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients

Studie von 2011: Soziale Angststörung nach Gabe von CBD wie bei gesunder Kontrollgruppe Die generalisierte soziale Angststörung (SAD) ist eine der häufigsten Angstzustände mit Beeinträchtigung des sozialen Lebens. Cannabidiol (CBD), eine wichtige nicht-psychotomimetische Verbindung der Cannabis-Sativa-Pflanze, hat sowohl beim Menschen als auch beim Tier anxiolytische Wirkungen gezeigt. Ziel dieser vorläufigen Studie war es, die Auswirkungen eines SPST-Tests (Simulation Public Speaking Test) auf gesunde Kontrollpatienten und therapienaive SAD-Patienten zu vergleichen, die eine Einzeldosis CBD oder Placebo erhielten. CBD verringerte die Angst, die kognitive Beeinträchtigung und das Unbehagen bei der Sprachleistung signifikant. Es wurden keine signifikanten Unterschiede zwischen der CBD Gruppe und gesunden Kontrollgruppe bei den kognitiven Beeinträchtigungen, Beschwerden und Warnfaktoren beobachtet. Die Placebogruppe wies im Vergleich zur Kontrollgruppe eine höhere Angst, kognitive Beeinträchtigung und unbehagen auf.

Ängste

Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival

The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial.

Fibromyalgie

The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration

Israeli research shows cannabidiol may slow Alzheimer’s disease

Alzheimer/Demenz

Cannabinoids inhibit cellular respiration of human oral cancer cells

The endocannabinoid system and migraine

Kopfschmerzen/Migräne

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

Studie von 2010: CBD sorgte für ein signifikant verringertes Angstempfinden Probanden erhielten in einem doppelblinden Verfahren eine orale Dosis CBD (400 mg) oder ein Placebo. Im Vergleich zu Placebo war CBD mit einer signifikant verringerten subjektiven Angst verbunden.

Ängste

Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy

Diabetes

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

Chronische Schmerzen

The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD)

Stress/PTBS

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

Magen-Darm-Beschwerden

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety and tolerability of THC: CBD extract in patients with intractable cancer-related pain

Chronische Schmerzen

Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington state

Arthritis

A population-based case-control study of marijuana use and head and neck squamous cell carcinoma

Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation

Cannabinoids for cancer treatment: progress and promise

Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach

Cannabinoids as a potential new drug therapy for the treatment of gliomas

Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels

Kopfschmerzen/Migräne

Degradation of endocannabinoids in chronic migraine and medication overuse headache

Kopfschmerzen/Migräne

Nabilone for the treatment of pain in fibromyalgia.

Fibromyalgie

Inhibition of cancer cell invasion by cannabinoids via increased cell expression of tissue inhibitor of matrix metalloproteinases-1

Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial

Chronische Schmerzen

A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain

Chronische Schmerzen

Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

Cannabinoids in pancreatic cancer: correlation with survival and pain

Alzheimer’s disease; taking the edge off with cannabinoids?

Alzheimer/Demenz

Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells

Expression of cannabinoid receptors and neurotrophins in human gliomas

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

Endocannabinoids in chronic migraine: CSF findings suggest a system failure

Kopfschmerzen/Migräne

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation

Alzheimer/Demenz

Oromucosal delta-9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial

Multiple Sklerose

Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial

Chronische Schmerzen

Dose-dependent Effects of Smoked Cannabis on Capsaicin-Induced Pain and Hyperalgesia in Healthy Volunteers

Chronische Schmerzen

Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes

Frontiers in pruritus research: scratching the brain for more effective itch therapy

Hautausschläge/Hautreizungen

Delta-9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemic T cells is regulated by translocation of Bad to mitochondria

Cannabis use in patients with multiple sclerosis

Multiple Sklerose

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice

Diabetes

The cannabinergic system as a target for anti-inflammatory therapies

Diabetes

A molecular link between the active component of marijuana and Alzheimer’s disease pathology

Alzheimer/Demenz

Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms of multiple sclerosis

Multiple Sklerose

Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief

Fibromyalgie

Neuroprotective and blood-retinal barrier preserving effects of cannabidiol in experimental diabetes

Diabetes

A pilot clinical study of delta-9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme

Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia

Alzheimer/Demenz

Delta-9-Tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation

Cannabinoid receptors in atherosclerosis

Hypertonie

Towards a therapeutic use of selective CB2 cannabinoid receptor ligands for atherosclerosis

Hypertonie

Marijuana use, diet, body mass index and cardiovascular risk factors

Hypertonie

Cannabis and cardiotoxicity

Hypertonie

Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

Preliminary assessment of the efficacy, tolerability and safety of a cannabis medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis

Arthritis

Endocannabinoids and the gastrointestinal tract

Magen-Darm-Beschwerden

Clinical pharmacodynamics of cannabinoids

Hypertonie

“Study finds no cancer-marijuana connection.”

Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma

Survey of Australians using cannabis for medical purposes

Fibromyalgie

Cannabinoids and the immune system: potential for the treatment of inflammatory diseases

Arthritis

The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase-2

Efficacy and tolerance of the cream containing structured physiological lipid endocannabinoids in the treatment of uremic pruritus: a preliminary study

Hautausschläge/Hautreizungen

Cardiac and vascular effects of cannabinoids: toward a therapeutic use?

Hypertonie

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis

Studie von 2005: Signifikant schmerzlindernde Wirkung und Krankheitsaktivität signifikant unterdrückt Studie zu Rheumatoide Arthritis (randomisierte doppelblinde Parallelgruppenstudie mit 58 Patienten über 5 Behandlungswochen) Nach der Behandlung mit THC/CBD 1:1 (Sativex) wurde eine signifikante analgetische Wirkung beobachtet und die Krankheitsaktivität signifikant unterdrückt.

Arthritis

The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract

Magen-Darm-Beschwerden

Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing

Magen-Darm-Beschwerden

The medicinal use of cannabis in the UK: results of a nationwide survey

Arthritis

Prevention of Alzheimer’s disease pathology by cannabinoids

Alzheimer/Demenz